Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle.
BMC Genomics
; 10: 96, 2009 Mar 02.
Article
em En
| MEDLINE
| ID: mdl-19254385
ABSTRACT
BACKGROUND:
Parasitic gastroenteritis caused by nematodes is only second to mastitis in terms of health costs to dairy farmers in developed countries. Sustainable control strategies complementing anthelmintics are desired, including selective breeding for enhanced resistance. RESULTS ANDCONCLUSION:
To quantify and characterize the genetic contribution to variation in resistance to gastro-intestinal parasites, we measured the heritability of faecal egg and larval counts in the Dutch Holstein-Friesian dairy cattle population. The heritability of faecal egg counts ranged from 7 to 21% and was generally higher than for larval counts. We performed a whole genome scan in 12 paternal half-daughter groups for a total of 768 cows, corresponding to the approximately 10% most and least infected daughters within each family (selective genotyping). Two genome-wide significant QTL were identified in an across-family analysis, respectively on chromosomes 9 and 19, coinciding with previous findings in orthologous chromosomal regions in sheep. We identified six more suggestive QTL by within-family analysis. An additional 73 informative SNPs were genotyped on chromosome 19 and the ensuing high density map used in a variance component approach to simultaneously exploit linkage and linkage disequilibrium in an initial inconclusive attempt to refine the QTL map position.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Mapeamento Cromossômico
/
Locos de Características Quantitativas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article