Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications.
J Virol
; 83(11): 5574-80, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19279087
ABSTRACT
KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmídeos
/
Proteínas Repressoras
/
Histonas
/
Proteínas de Ligação a DNA
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article