Acromegaly accompanied by Turner syndrome with 47,XXX/45,X/46,XX mosaicism.
Intern Med
; 48(6): 447-53, 2009.
Article
em En
| MEDLINE
| ID: mdl-19293545
ABSTRACT
A 33-year-old woman was hospitalized for examination of edematous laryngopharynx. She was acromegalic. A pituitary adenoma with elevated serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) was detected, indicating acromegaly caused by GH-secreting pituitary adenoma. Multiple pigmented nevi were also noted without overt short stature and cubitus valgus. Chromosome analysis revealed that she had contracted Turner syndrome with 47,XXX/45,X/46,XX mosaicism. Transsphenoidal resection of the tumor decreased serum GH and IGF-I levels, but the edema was not improved. Both premature ovarian failure and hypertension appeared after surgery. This case may indicate the important relationships between GH/IGF-I and Turner syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Acromegalia
/
Cromossomos Humanos X
/
Mosaicismo
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article