Der p2 activates airway smooth muscle cells in a TLR2/MyD88-dependent manner to induce an inflammatory response.
J Cell Physiol
; 220(2): 311-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19326394
ABSTRACT
Der p2 is a major allergen from Dermatophagoides pteronyssinus, the main species of house dust mite and a major inducer of asthma, inducing harmful respiratory inflammatory responses by activating cells in the respiratory tract, leading to an unstable status. We hypothesize that Der p2 may induce local inflammatory responses by directly affecting airway smooth muscle (ASM) cells. In this study, we demonstrated that Der p2 raised nuclear factor-kappa B (NF-kappaB) and extracellular signal-regulated kinase (ERK) 1/2 activation and induced a high level of proinflammatory cytokines expression in primary cultured ASM cells. Der p2 activated the MyD88 signaling pathway through toll-like receptor (TLR) 2, not through TLR4. Notably, Der p2 stimulated ASM cells to increase phosphorylation of ERK1/2 and expression of c-Fos, which were also important in the T helper type 2 (Th2) immune response. These results suggest that Der p2 induces asthma through the MyD88 signaling pathway in respiratory tissue.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
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Asma
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Miócitos de Músculo Liso
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Antígenos de Dermatophagoides
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Receptor 2 Toll-Like
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Fator 88 de Diferenciação Mieloide
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Inflamação
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article