Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.
Viral Immunol
; 22(2): 139-44, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19327001
ABSTRACT
We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rotavirus
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Diarreia
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Osteopontina
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Imunidade Inata
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Fatores Imunológicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article