Concentrations of voriconazole in healthy and inflamed lung in rats.
Antimicrob Agents Chemother
; 53(6): 2684-6, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19332681
ABSTRACT
By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Pirimidinas
/
Triazóis
/
Pulmão
/
Antifúngicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article