Abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol.
Acta Obstet Gynecol Scand
; 88(6): 673-9, 2009.
Article
em En
| MEDLINE
| ID: mdl-19353331
ABSTRACT
OBJECTIVE:
To investigate the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitory of metalloproteinase-1 (TIMP-1) in women who had undergone a medical abortion and explore their possible role in the mechanism of prolonged uterine bleeding after a mifepristone-misoprostol abortion.DESIGN:
Cross-sectional study.SETTING:
Tertiary referral university hospital. SAMPLE Forty women were recruited following a medical abortion with mifepristone and misoprostol, 20 with duration of bleeding >14 days and 20 with duration of bleedingMEASURES:
Histology was analyzed by light microscope and expression of MMP-9 and TIMP-1 was semi-quantitatively evaluated.RESULTS:
Histological examination showed residual villi and trophoblasts with inflammatory cell infiltration in women with duration of bleeding >14 days after a medical abortion (bleeding group), whereas each sample of women with duration of bleedingCONCLUSION:
This study documents that prolonged bleeding after a medical abortion with mifepristone and misoprostol is associated with retained products of conception with inflammatory cell infiltration, abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Uterina
/
Abortivos
/
Mifepristona
/
Misoprostol
/
Aborto Induzido
/
Inibidor Tecidual de Metaloproteinase-1
/
Metaloproteinase 9 da Matriz
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article