Structural enzymology of polyketide synthases.
Methods Enzymol
; 459: 17-47, 2009.
Article
em En
| MEDLINE
| ID: mdl-19362634
ABSTRACT
This chapter describes structural and associated enzymological studies of polyketide synthases, including isolated single domains and multidomain fragments. The sequence-structure-function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. Structural enzymology sheds light on sequence and structural motifs that are important for the precise timing, substrate recognition, enzyme catalysis, and protein-protein interactions leading to the extraordinary structural diversity of naturally occurring polyketides.
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1
Base de dados:
MEDLINE
Assunto principal:
Policetídeo Sintases
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article