Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis.
Clin Transl Oncol
; 11(4): 243-9, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19380302
ABSTRACT
INTRODUCTION:
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and retinoic acid receptors (RAR/RXR) belong to the nuclear steroid receptor family. In vitro studies have suggested that PPAR-gamma ligands are highly effective in preventing mammary tumours and these effects are enhanced by some retinoids. However, in vivo anti-initiator and anti-promoter efficacies of this combination are not clear. AIM ANDMETHODS:
The present study aimed to investigate the chemopreventive efficacies of the PPAR-gamma ligand rosiglitazone (200 microg/kg/day), synthetic retinoid fenretinide (0.3 mg/kg/day) and their combination on a DMBA-induced rat mammary carcinogenesis model.RESULTS:
In the rosiglitazone group, no malignant tumour developed, apart from the lowest proliferative mammary lesions. In the fenretinide group, 30% developed a malignant tumour but there were no benign tumours. Cancer incidences were 61.5% and 10% in the control and combination groups respectively.CONCLUSIONS:
Our results showed that the PPAR-gamma ligand rosiglitazone and synthetic retinoid fenretinide have potent chemopreventive properties against in vivo mammary carcinogenesis; however, the efficacies were not enhanced by their combination.
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Base de dados:
MEDLINE
Assunto principal:
Fenretinida
/
Tiazolidinedionas
/
Hipoglicemiantes
/
Neoplasias Mamárias Experimentais
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article