Simultaneous determination of voriconazole and posaconazole concentrations in human plasma by high-performance liquid chromatography.
Antimicrob Agents Chemother
; 53(7): 3140-2, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19380591
ABSTRACT
A simple, sensitive, and selective high-performance liquid chromatographic method for the simultaneous determination of voriconazole and posaconazole concentrations in human plasma was developed and validated. Quantitative recovery following liquid-liquid extraction with diethyl ether was achieved. Linearity ranged from 0.10 to 20.0 microg/ml for voriconazole and from 0.05 to 10.0 microg/ml for posaconazole. The intra- and interday coefficients of variation were less than 8.5%, and the lower limits of quantitation were <0.05 microg/ml.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Triazóis
/
Cromatografia Líquida de Alta Pressão
/
Antifúngicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article