The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients.
Otolaryngol Head Neck Surg
; 140(5): 748-51, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19393423
ABSTRACT
INTRODUCTION:
Considering the different clinical aspects of polyps in asthmatic and nonasthmatic patients, we aimed to explore their histopathological characteristics. MATERIAL ANDMETHODS:
Twenty-five asthmatic patients and 25 nonasthmatic patients with polypoid chronic rhinosinusitis (29 male, 21 female; mean age 41.3 +/- 13.27; range 15-78 years) were enrolled in the study to be compared on the basis of histopathological characteristics. They were compared according to the following seven light microscopicfindings:
basement membrane thickness, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocytic infiltration, and polymorphonuclear infiltration.RESULTS:
Basement membrane thickening, goblet cell hyperplasia, and eosinophilic and lymphocytic infiltration were more prominent in the asthmatic compared with the nonasthmatic group (P < 0.05), whereas polymorphonuclear infiltration was more prominent in nonasthmatics (P < 0.05). No statistically significant differences were found between the two groups with regard to submucosal gland hyperplasia or subepithelial edema.CONCLUSION:
Asthmatic patients present histopathological characteristics of a marked chronic inflammatory reaction, which might explain the negative effect on chronic rhinosinusitis outcome and the severity of the disease in this group.
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Base de dados:
MEDLINE
Assunto principal:
Asma
/
Pólipos Nasais
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article