Association of TLR4 polymorphisms with Behcet's disease in a Korean population.
Rheumatology (Oxford)
; 48(6): 638-42, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19395541
ABSTRACT
OBJECTIVES:
HLA-B51 is strongly associated with Behçet's disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a Japanese population. To confirm these results, we investigated polymorphisms in the TLR4 gene in Korean patients with BD.METHODS:
In this study, 119 patients with BD and 141 healthy controls were enrolled; every participant was a Korean. Nine single nucleotide polymorphisms previously detected in TLR4 by direct sequencing were analysed for an association with BD.RESULTS:
The most frequent haplotype, TAGCGGTAA, was significantly increased in HLA-B*51-positive BD patients (49.5%), compared with healthy control participants [32.3%; P = 0.029; odds ratio (OR) = 2.01; 95% CI 1.25-3.23]. This haplotype was also significantly increased in BD patients with arthritis (48.2%; P = 0.003; OR = 1.96; 95% CI 1.26-3.26). There were no significant differences in the allele and genotype frequencies of patients and controls for each single nucleotide polymorphism.CONCLUSIONS:
The haplotype of TLR4 may increase the risk for developing BD and the complication of arthritis in the Korean population.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Behçet
/
Polimorfismo de Nucleotídeo Único
/
Receptor 4 Toll-Like
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article