Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults.
Am J Clin Nutr
; 89(6): 1808-14, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19403637
ABSTRACT
BACKGROUND:
Selenium, a potential cancer prevention agent currently being tested against prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), plays an integral role in thyroid metabolism. The effects of long-term selenium supplementation on thyroid hormone concentrations are unknown.OBJECTIVE:
The objective was to investigate the effects of long-term selenium supplementation on thyroid hormone concentrations.DESIGN:
Twenty-eight healthy adults took 200 microg selenomethionine/d for 28 mo. The thyroid hormones triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH) were measured in plasma for 4 mo before supplementation and quarterly during supplementation. The assay methods were changed midstudy; the results of the 2 methods were not comparable. Therefore, one analysis was conducted based on the results of the first method, and a second analysis was based on all of the data, adjusted for the change. Serial data collection permitted a test for trends rather than simply a difference between initial and final values.RESULTS:
By 9 mo, mean (+/-SEM) plasma selenium concentrations had increased from 1.78 +/- 0.07 micromol/L at baseline to 2.85 +/- 0.11 micromol/L for men and from 1.64 +/- 0.04 to 3.32 +/- 0.1.2 micromol/L for women. T3 concentrations in men increased 5% per year (P = 0.01). T4 and TSH concentrations were unchanged.CONCLUSIONS:
Selenium supplementation produced no clinically significant changes in thyroid hormone concentrations. A small but statistically significant increase in T3 concentrations was noted in men, with no corresponding decreases in TSH. A subset of SELECT subjects might be monitored periodically for changes during long-term selenium supplementation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Selenometionina
/
Tiroxina
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Oligoelementos
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Tri-Iodotironina
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Tireotropina
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Suplementos Nutricionais
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article