An eikonal-curvature equation for action potential propagation in myocardium.
J Math Biol
; 29(7): 629-51, 1991.
Article
em En
| MEDLINE
| ID: mdl-1940663
ABSTRACT
We derive an "eikonal-curvature" equation to describe the propagation of action potential wavefronts in myocardium. This equation is used to study the effects of fiber orientation on propagation in the myocardial wall. There are significant computational advantages to the use of an eikonal-curvature equation over a full ionic model of action potential spread. With this model, it is shown that the experimentally observed misalignment of spreading action potential "ellipses" from fiber orientation in level myocardial surfaces is adequately explained by the rotation of fiber orientation through the myocardial wall. Additionally, it is shown that apparently high propagation velocities on the epicardial and endocardial surfaces are the result of propagation into the midwall region and acceleration along midwall fibers before reemergence at an outer surface at a time preceding what could be accomplished with propagation along the surface alone.
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Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Coração
/
Modelos Cardiovasculares
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article