A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.
Bioorg Med Chem Lett
; 19(12): 3268-70, 2009 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-19423346
ABSTRACT
6-Methyl-3-phenylcoumarins 3-6 were designed, synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. The synthesis of these new compounds (resveratrol-coumarin hybrids) was carried out with good yield by a Perkin reaction, from the 5-methylsalicylaldehyde and the corresponding phenylacetic acid. They show high selectivity to the MAO-B isoenzyme, with IC(50) values in the nanomolar range. Compound 5 is the most active compound and is several times more potent and selective than the reference compound, R-(-)-deprenyl.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Cumarínicos
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Inibidores da Monoaminoxidase
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article