Stability of the mixture of technetium-99m human serum albumin and lidocaine hydrochloride for clinical application.
Nucl Med Commun
; 30(7): 494-7, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19430321
ABSTRACT
AIM:
To evaluate the stability of the mixture of technetium-99m (99mTc) human serum albumin (HSA) with the local anesthetic lidocaine hydrochloride. MATERIALS ANDMETHODS:
We assessed three preparations of the radiotracer, 99mTc-HSA, filtered 99mTc-HSA, and a mixture of 99mTc-HSA with lidocaine hydrochloride and then filtered. Time sequence evaluation was performed on all the specimens (n= 10) at 0, 30, 60, 90, 120, 150, and 180 min after preparation. Measurements of radiochemical purity as labeling stability and pH value change were conducted for each group of specimens.RESULTS:
We found no definite difference in the stability before and after the filtering procedure for 99mTc-HSA. However, we showed a decline of stability in the mixture of 99mTc-HSA with lidocaine. The filtered specimens showed a relatively higher pH value, towards a more neutral status, as compared with the unfiltered specimens.CONCLUSION:
Though pain relief for the patient receiving sentinel lymph node mapping is important, a preparation of a mixture of 99mTc-HSA and lidocaine may cause radiolabeling instability. Furthermore, compared with the filtered 99mTc-sulfur colloid, a filtering procedure does not change the labeling stability of the 99mTc-HSA. On the contrary, the filtered preparation was neutralized closer to the physiologic condition. For lymphoscintigraphic studies,our results suggested that pretreatment with local anesthesia followed by subdermal injection of a filtered 99mTc-HSA rather than a pre-mixture with lidocaine is appropriate for clinical application.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Agregado de Albumina Marcado com Tecnécio Tc 99m
/
Anestésicos Locais
/
Lidocaína
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article