High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics.
Leuk Res
; 33(12): 1706-9, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19457552
ABSTRACT
The PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p=0.015) and RFS (p=0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC>50x10(9)/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a assessment could contribute to improve the molecular-based risk stratification in CN-AML.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Regulação Neoplásica da Expressão Gênica
/
Fatores de Transcrição Forkhead
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article