Effect of 2-octyl-cyanoacrylate on ischemic anastomosis of the left colon.
J Invest Surg
; 22(3): 188-94, 2009.
Article
em En
| MEDLINE
| ID: mdl-19466656
ABSTRACT
INTRODUCTION:
2-octyl-cyanoacrylate may be a good alternative in ischemic colon anastomosis without impairment of tissue perfusion.METHODS:
Forty male Wistar albino rats were randomized into four experimental groups (n = 10 in each group). In group 1 (control), a well-perfused left colonic segment was transected, and free ends were anastomosed by propylene sutures. In groups 2, 3, and 4, the animals underwent a standardized surgical procedure to induce ischemic left colon anastomosis. In group 2, an end-to-end anastomosis was created using six interrupted 6-0 polypropylene sutures between ischemic edges. In group 3, after approximating the mesenteric and antimesenteric edges of the anastomosis with two 6-0 polypropylene sutures, 2-octyl-cyanoacrylate was applied between the edges. In group 4, anastomosis was created by the same technique as described in group 2, and additionally 2-octyl-cyanoacrylate was applied on suture line. Rats were killed on day 4 following operation. Anastomotic integrity, intraperitoneal adhesion scores, anastomotic bursting pressures, and tissue hydroxyproline levels were recorded. Histopathological examination of the anastomosis was also performed.RESULTS:
There were no statistically significant differences among groups with respect to anastomotic integrity (p =.142). The mean bursting pressure values were 81.1 +/- 23.83, 43.3 +/- 26.06, 15.8 +/- 11.3, and 17.6 +/- 18.02 in groups 1, 2, 3, and 4, respectively. There were no statistically significant differences among groups 2, 3, and 4 with respect to tissue hydroxyproline levels and bursting pressure levels. The highest adhesion scores were observed in groups 3 and 4.DISCUSSION:
2-octyl cyanoacrylate does not have additional advantages in the healing of experimental ischemic colon anastomosis.
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Base de dados:
MEDLINE
Assunto principal:
Adesivos Teciduais
/
Colo
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Cianoacrilatos
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Isquemia
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article