Alzheimer's disease: new approaches to drug discovery.
Curr Opin Chem Biol
; 13(3): 303-8, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19467915
ABSTRACT
In this work, we review and comment upon the challenges and the 'quo vadis' in Alzheimer's disease drug discovery at the beginning of the new millennium. We emphasize recent approaches that, moving on from a target-centric approach, have produced innovative molecular probes or drug candidates. In particular, the discovery of endosome-targeted BACE1 inhibitors and mitochondria-targeted antioxidants represents a significant advance in Alzheimer's research and therapy. The case study of the development of rasagiline provides an excellent example to support the validity of the multitarget-designed ligand approach to the search for effective medicines for combating Alzheimer's disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Descoberta de Drogas
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article