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Alzheimer's disease: new approaches to drug discovery.
Bolognesi, Maria L; Matera, Riccardo; Minarini, Anna; Rosini, Michela; Melchiorre, Carlo.
Afiliação
  • Bolognesi ML; Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Curr Opin Chem Biol ; 13(3): 303-8, 2009 Jun.
Article em En | MEDLINE | ID: mdl-19467915
ABSTRACT
In this work, we review and comment upon the challenges and the 'quo vadis' in Alzheimer's disease drug discovery at the beginning of the new millennium. We emphasize recent approaches that, moving on from a target-centric approach, have produced innovative molecular probes or drug candidates. In particular, the discovery of endosome-targeted BACE1 inhibitors and mitochondria-targeted antioxidants represents a significant advance in Alzheimer's research and therapy. The case study of the development of rasagiline provides an excellent example to support the validity of the multitarget-designed ligand approach to the search for effective medicines for combating Alzheimer's disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Descoberta de Drogas / Doença de Alzheimer Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Descoberta de Drogas / Doença de Alzheimer Idioma: En Ano de publicação: 2009 Tipo de documento: Article