PTPRR, cerebellum, and motor coordination.
Cerebellum
; 8(2): 71-3, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19488825
ABSTRACT
Tyrosine phosphorylation is a powerful mechanism of modulation for proliferation, differentiation, and functioning of neurons. The protein products of the neuronal mouse gene PTPRR are physiological regulators of mitogen-activated protein kinase (MAPK) activities. PTPRR(-/-) mice display deficits of motor coordination and balance skills. PTPRR gene orthologues are found in many vertebrates. Recent observations suggest that the human episodic ataxia 2 (EA2) and spinocerebellar ataxia types 6 (SCA6), 12 (SCA12), and 14 (SCA14) might be associated with impaired phosphorylation levels of cerebellum calcium channels and receptors. The concept that MAPK signaling is a key process in tuning synaptic plasticity in cerebellar circuits is now emerging, with numerous implications for understanding cerebellar functions and cerebellar disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cerebelares
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Cerebelo
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Sistema de Sinalização das MAP Quinases
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Proteínas Tirosina Fosfatases Classe 7 Semelhantes a Receptores
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article