The augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity.
Biosci Biotechnol Biochem
; 73(6): 1419-21, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19502751
ABSTRACT
We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Sobrevivência Celular
/
Isotiocianatos
/
Glutationa
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article