Novel antimicrobial peptides isolated from skin secretions of the Mexican frog Hyla eximia.
Protein Pept Lett
; 16(11): 1371-8, 2009.
Article
em En
| MEDLINE
| ID: mdl-19508207
ABSTRACT
In this work, we describe the original characterization of peptides and proteins present in the skin secretions of the Mexican amphibian Hyla eximia. To this purpose, a novel water/dark extraction method, as well as the classic electrical stimulation procedure, was applied in order to extract the skin secretion. Two novel antimicrobial peptides He-1 and He-2 were sequenced. In addition, a molecular mass fingerprint revealed more than one hundred different molecules. Eight peptides in homogeneous form were assayed against five species of bacteria. Thereafter, the peptide He-2 demonstrated high antiparasitic activity against ookinete forms of malaria parasites at low concentration.
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Base de dados:
MEDLINE
Assunto principal:
Anuros
/
Pele
/
Secreções Corporais
/
Peptídeos Catiônicos Antimicrobianos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article