Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Bioorg Med Chem Lett
; 19(15): 4446-9, 2009 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-19525110
ABSTRACT
A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various amide modifications and substitution on the left side phenyl ring were prepared and found to show significant inhibitory activities towards both CXCR2 and CXCR1 receptors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenol
/
Ciclobutanos
/
Receptores de Interleucina-8A
/
Receptores de Interleucina-8B
/
Diaminas
/
Amidas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article