[Severe microcytic anemia with megaloblastic changes in the bone marrow. A hematological paradoxon?]. / Schwere mikrozytäre Anämie bei megaloblastären Veränderungen im Knochenmark : Ein hämatologisches Paradoxon?
Internist (Berl)
; 50(7): 881-6, 2009 Jul.
Article
em De
| MEDLINE
| ID: mdl-19536514
ABSTRACT
We discuss the case of a 32 year-old male with severe microcytic anemia (hemoglobin 2,9 g/dl) and megaloblastic changes in the bone marrow. The patient reported of substantial dietary weight loss. The family history was positive for beta-thalassemia. Previous blood work showed iron deficiency with mild anemia. Further work-up verified beta-thalassemia minor and revealed severely decreased vitamin B12 levels with positive anti intrinsic-factor antibodies, pathognomonic for autoimmune pernicious anemia. The paradoxon therefore dissolved as a pernicious anemia with megaloblastic changes with microcytic erythrocytes due to beta-thalassemia.
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1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina B 12
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Talassemia beta
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Anemia Perniciosa
Idioma:
De
Ano de publicação:
2009
Tipo de documento:
Article