Preparation and in-vitro evaluation of 4-benzylsulfanylpyridine-2-carbohydrazides as potential antituberculosis agents.
Arch Pharm (Weinheim)
; 342(7): 394-404, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19536781
ABSTRACT
A set of 4-benzylsulfanylpyridine-2-carbohydrazides was synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, non-tuberculous mycobacteria, and multidrug-resistant M. tuberculosis. The activities expressed as the minimum inhibitory concentration (MIC) fall into a range of 2 to 125 micromol/L, most often 4 to 32 micromol/L. The results revealed that the substituents on the benzyl moiety do not influence the antimycobacterial efficacy. The substances exhibited similar activities against sensitive and resistant strains of M. tuberculosis. Furthermore, compounds show low antiproliferative effect and cytotoxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Hidrazinas
/
Antituberculosos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article