Inhibition of superoxide anion production by extracellular acidification in neutrophils.
Cell Immunol
; 259(1): 21-6, 2009.
Article
em En
| MEDLINE
| ID: mdl-19539899
ABSTRACT
Extracellular acidification inhibited formyl-Met-Leu-Phe- or C5a-induced superoxide anion (O(2)(-)) production in differentiated HL-60 neutrophil-like cells and human neutrophils. A cAMP-increasing agonist, prostaglandin E(1), also inhibited the formyl peptide-induced O(2)(-) production. The inhibitory action on the O(2)(-) production by extracellular acidic pH was associated with cAMP accumulation and partly attenuated by H89, a protein kinase A inhibitor. A significant amount of mRNAs for T-cell death-associated gene 8 (TDAG8) and other proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-family receptors is expressed in these cells. These results suggest that cAMP/protein kinase A, possibly through proton-sensing G-protein-coupled receptors, may be involved in extracellular acidic pH-induced inhibition of O(2)(-) production.
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1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases Dependentes de AMP Cíclico
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AMP Cíclico
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Superóxidos
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Receptores Acoplados a Proteínas G
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Neutrófilos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article