[Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin].
Yao Xue Xue Bao
; 44(4): 386-9, 2009 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-19545056
ABSTRACT
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
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Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
/
Isoflavonas
/
Lipídeos
/
Fígado
/
Hipolipemiantes
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article