Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis.
J Pediatr Endocrinol Metab
; 22(4): 339-44, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19554808
ABSTRACT
BACKGROUND:
Although thyroid ultrasound is a valuable tool for the diagnosis and follow-up of patients with Hashimoto's thyroiditis (HT), classical sonographic findings are not always present.AIM:
To calculate the time needed for children with HT and normal ultrasound at diagnosis to develop characteristic sonographic findings. PATIENTS ANDMETHODS:
105 children (23 male and 82 female) with HT (mean age 9.4 +/- 2.9 years) were studied. Physical examination and measurements of TSH and fT4 levels were performed at diagnosis, at 3-month intervals for the first year, and twice yearly thereafter. Thyroid ultrasound was performed at diagnosis and twice yearly thereafter. The median follow-up duration was 18 months (range 6-61 months).RESULTS:
The time needed for 30%, 50%, and 70% of children to demonstrate an abnormal thyroid sonographic pattern was 4, 7, and 14 months, respectively. Important factors accelerating sonographic changes were goiter (p = 0.023), hypothyroidism (p = 0.0255), and seropositivity for both thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) autoantibodies (p = 0.0005).CONCLUSION:
Sonographic findings of HT are present in 37% of children at diagnosis. Fifty percent of children with normal initial thyroid US will develop changes within 7 months; however, characteristic findings may not develop for over 4 years.
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Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Doença de Hashimoto
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article