No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population.
DNA Cell Biol
; 28(10): 521-5, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19563249
ABSTRACT
The clinical features suggest that genetic factors may have a strong influence on susceptibility to coronary artery disease (CAD). The aim of this study was to investigate the association between FokI (rs2228570) and BsmI (rs1544410) of the vitamin D receptor (VDR) gene polymorphisms and patients with CAD in a Chinese population. One hundred and fifty-two CAD patients and 212 healthy controls were genotyped for the FokI and BsmI polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism. No significant differences were observed in the genotype and allele frequencies of the FokI and BsmI polymorphisms between the cases and controls (For FokI odds ratio = 1.11, 95% confidence interval 0.83-1.50; for BsmI odds ratio = 0.74, 95% confidence interval 0.44-1.23). There was no significant difference in the genotype distribution or the allele frequencies of VDR FokI and BsmI between two groups in a Chinese population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Doença da Artéria Coronariana
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Receptores de Calcitriol
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article