Endocytosis, asymmetric cell division, stem cells and cancer: unus pro omnibus, omnes pro uno.
Mol Oncol
; 3(4): 339-53, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19581131
ABSTRACT
Carcinogenesis can be initiated in adult stem cells, suggesting that tumours arise as a consequence of stem-cell dysfunction. In the fruitfly, cancer arises in stem cells that fail to undergo asymmetric cell division. In flies and mammals, a specific regulation of the endocytic trafficking machinery allows stem cells to self-renew and generate the differentiating cells required to form and maintain mature organs. We review recent findings suggesting that an understanding of the relationship between endocytosis, asymmetric cell division, stem cells and cancer will be crucial to unravel the cell biological basis of tumourigenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Divisão Celular
/
Endocitose
/
Neoplasias
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article