Manidipine in hypertensive patients with metabolic syndrome: the MARIMBA study.
Expert Rev Cardiovasc Ther
; 7(7): 863-9, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19589122
ABSTRACT
OBJECTIVES:
To evaluate the effects of manidipine versus amlodipine on blood pressure, albuminuria, insulin sensitivity, adiponectin, TNF-alpha and C-reactive protein in nondiabetic subjects with metabolic syndrome (ATP-III definition), including impaired fasting glucose (>5.6 mmol/l) and hypertension.METHODS:
In total, 64 patients were recruited and randomly assigned to manidipine 20 mg versus amlodipine 10 mg (for 12 +/- 2 weeks).RESULTS:
Blood pressure was reduced to a similar extent (p < 0.001) by both treatments. Albuminuria was significantly reduced by manidipine (-37.3%; p = 0.003), but not by amlodipine. C-reactive protein was reduced similarly (p < 0.01) by both treatments. Plasma adiponectin was increased (32.9%; p = 0.011) and plasma TNF-alpha was reduced by manidipine (-37.1%; p = 0.019), but neither was significantly changed by amlodipine. The HOMA insulin resistance index was significantly reduced by manidipine (-21.3%; p = 0.007), but not by amlodipine (-8.3%; p = 0.062). Tolerability with manidipine was superior to that with amlodipine (p = 0.04).CONCLUSION:
These data support the added value of manidipine in renal and metabolic protection beyond blood pressure reduction in the treatment of hypertensive patients with metabolic syndrome.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Di-Hidropiridinas
/
Anlodipino
/
Síndrome Metabólica
/
Hipertensão
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article