Delivering cytokines at tumor site: The immunocytokine-conjugated anti-EDB-fibronectin antibody case.
Immunobiology
; 214(9-10): 800-10, 2009.
Article
em En
| MEDLINE
| ID: mdl-19625102
ABSTRACT
Although considerable efforts have been made in the discovery of new agents for cancer treatment, several promising therapeutics cannot be applied systemically because of their severe side effects. This is the case for various recombinant pro-inflammatory cytokines that, despite their potent anti-cancer activity, can not find their way to clinical exploitation due to their devastating toxicity shown during dose escalation to therapeutically active concentrations. To circumvent these problems, an elegant and efficient way to accumulate therapeutic agents at the tumor site, thus reducing systemic side effects, is their conjugation to tumor-specific antibodies. Here, we review preclinical data about immunocytokines conjugated to a promising single-chain human antibody that selectively targets tumor-associated stroma and blood vessels by binding with high affinity and specificity to the extra domain-B (EDB) of fibronectin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sialoglicoproteínas
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Citocinas
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Linfocinas
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Sistemas de Liberação de Medicamentos
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article