Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology.
J Alzheimers Dis
; 18(3): 509-13, 2009.
Article
em En
| MEDLINE
| ID: mdl-19661628
Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Memantina
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Emaranhados Neurofibrilares
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Doença de Alzheimer
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Antiparkinsonianos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article