MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma.
Br J Dermatol
; 161(5): 1112-8, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19673870
ABSTRACT
BACKGROUND:
The genetic alterations that drive the transition from actinic keratoses (AKs) to cutaneous squamous cell carcinomas (SCCs) have not been defined precisely. Amplification and/or overexpression of the MYC proto-oncogene have been demonstrated in several human, malignant tumours including head and neck SCCs.OBJECTIVES:
To evaluate the presence of MYC genomic aberrations in both AKs and SCCs.METHODS:
Skin biopsy specimens corresponding to AKs, SCCs and control samples were included in two paraffin-embedded tissue microarrays. MYC cytogenetic profile was evaluated by fluorescence in situ hybridization (FISH). The results obtained were compared with MYC immunohistochemical expression.RESULTS:
Twenty-three AKs and 30 SCCs were evaluated. MYC numerical aberrations were observed in eight of 23 (35%) AKs and 19 of 30 (63%) SCCs (P = 0.05). MYC numerical aberrations were more frequent in moderately to poorly differentiated SCCs (77%) when compared with well-differentiated SCCs (25%; P = 0.027). A significant association between copy number gains of MYC by FISH analysis and MYC protein expression was demonstrated.CONCLUSIONS:
MYC gains and amplifications are frequent cytogenetic abnormalities in SCCs and may play a relevant role in promoting SCC undifferentiation and tumoral progression.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Carcinoma de Células Escamosas
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Genes myc
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Aberrações Cromossômicas
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Progressão da Doença
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Ceratose Actínica
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article