Detection of 2H-1,4-thiazine-5,6-dihydro-3-carboxylic acid (aminoethylcysteine ketimine) in the bovine brain.
Biochem Biophys Res Commun
; 166(3): 1251-6, 1990 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-1968336
ABSTRACT
2H-1,4-Thiazine-5,6-dihydro-3-carboxylic acid (trivial name aminoethylcysteine ketimine) is a cyclic sulfur-containing imino acid detected in bovine brain extracts by means of three different procedures. Gas liquid chromatography of protein-free extracts of five bovine brains revealed the presence of this compound at concentrations ranging from 2 to 3 nmol/g wet weight of tissue. The enzymatic method based on the inhibition of D-amino acid oxidase activity by aminoethylcysteine ketimine together with an high-performance liquid chromatography procedure confirm the identification and quantitations obtained with gas liquid chromatography. The discovery of this compound structurally similar to pipecolic acid opens the question of its physiological role in the central nervous system.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
Aminoácidos Sulfúricos
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article