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The toxic effect of different concentrations of povidone iodine on the rabbit's cornea.
Jiang, Jin; Wu, Miaoqin; Shen, Ting.
Afiliação
  • Jiang J; Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Cutan Ocul Toxicol ; 28(3): 119-24, 2009.
Article em En | MEDLINE | ID: mdl-19694608
OBJECTIVES: To investigate the effects of polyvinylpyrrolidone (i.e., povidone) iodine (PVP-I) in different concentrations on the rabbit's cornea. METHODS: PVP-I in various concentrations was instilled into the conjunctival sac and injected into the anterior chamber independently. The toxicity to the cornea was assessed by fluorescence dye, specular microscopy, and corneal pachymetry. RESULTS: After conjunctival sac PVP-I instillation, severe epithelial damage was observed at the concentrations of 5.0% and 2.5%. After anterior chamber PVP-I injection, significant corneal edema was observed at the concentrations of 2.0% and 1.5%. CONCLUSIONS: It can be safe and feasible to use 0.5% or 1.0% concentrations of PVP-I in conjunctival sac instillation for preoperative antisepsis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Povidona-Iodo / Testes de Toxicidade / Córnea / Anti-Infecciosos Locais Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Povidona-Iodo / Testes de Toxicidade / Córnea / Anti-Infecciosos Locais Idioma: En Ano de publicação: 2009 Tipo de documento: Article