Cytodiagnostic problems in cervicovaginal smears from symptomatic breast cancer patients on tamoxifen therapy.
Acta Cytol
; 53(4): 383-8, 2009.
Article
em En
| MEDLINE
| ID: mdl-19697721
ABSTRACT
OBJECTIVE:
To evaluate the effect of tamoxifen on cervicovaginal epithelium, identify tamoxifen-related changes that mimic cancer and detennine the morphologic features differentiating the 2 changes. STUDYDESIGN:
Cervicovaginal smears from 153 conventionally treated primary breast cancer patients presenting with gynecologic symptoms were studied.RESULTS:
All 153 patients presented with menorrhagia or irregular periods. Of 4 patients with a cytodiagnosis of atypical glandular changes, 2 had negative histology; 1 each had a uterine leiomyoma and endometrial hyperplasia. Of the 6 cases reported as adenocarcinoma, 3 were histologically confirmed, and the others were false positives. Conversely, 1 false negative case histologically was an endometrioid carcinoma.CONCLUSION:
Our study revealed that reactive glandular cells are a cause of false positive diagnoses. Tamoxifen-associated cellular changes can mimic morphologic features of cancer. To avoid diagnostic errors, cervicovaginal smears should be repeated after discontinuing tamoxifen treatment. Clinical correlation is mandatory. Regular follow-up with cervicovaginal smears from patients on tamoxifen treatment is recommended.
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Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Vagina
/
Neoplasias Vaginais
/
Esfregaço Vaginal
/
Neoplasias do Colo do Útero
/
Colo do Útero
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article