Baseline cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy.
Dev Med Child Neurol
; 52(1): 22-6, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19702836
ABSTRACT
AIM:
Epilepsy is associated with difficulties in cognition and behavior in children. These problems have been attributed to genetics, ongoing seizures, psychosocial issues, underlying abnormality of the brain, and/or antiepileptic drugs. In a previous study, we found baseline cognitive differences between children with partial versus generalized and convulsive versus non-convulsive seizures. Measures in that study focused primarily on IQ scores. In the present study, we assessed baseline function with respect to new learning, attention, and memory, thus providing a more comprehensive profile than our previous study.METHOD:
We examined 57 children (42 females, 15 males), aged 6 to 17 years (mean 10y 1mo, SD 2y 9mo), with new-onset, idiopathic epilepsy, using tests of cognitive function reflective of new learning, memory, and attention. Seizures were classified as generalized convulsive (n=5), generalized non-convulsive (n=18), or focal (n=34). Focal seizures were divided into unilateral versus bilateral independent foci, and presence versus absence of secondary generalization.RESULTS:
Attention was a particular area of weakness across all groups. The Vocabulary score of an intelligence screen was higher for the focal seizure groups (p=0.012), primarily because of a difference between the unilateral focal and the primary generalized groups (p<0.047). Children with generalized, non-convulsive seizures performed significantly worse than the focal group on a measure of short-term auditory memory (p=0.019). All groups performed poorly on a test of visual-motor speed.INTERPRETATION:
These findings suggest intrinsic abnormalities in children with new-onset, idiopathic epilepsy at baseline.
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Base de dados:
MEDLINE
Assunto principal:
Determinação da Personalidade
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Transtornos do Comportamento Infantil
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Epilepsias Parciais
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Epilepsia Generalizada
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Transtornos Cognitivos
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Transtornos das Habilidades Motoras
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Testes Neuropsicológicos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article