Delivery of RNAi reagents in murine models of obesity and diabetes.
J RNAi Gene Silencing
; 3(1): 225-36, 2006 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-19771218
ABSTRACT
RNA interference (RNAi) is an exciting new tool to effect acute in vivo knockdown of genes for pharmacological target validation. Testing the application of this technology to metabolic disease targets, three RNAi delivery methods were compared in two frequently utilized preclinical models of obesity and diabetes, the diet-induced obese (DIO) and B6.V-Lep
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MEDLINE
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En
Ano de publicação:
2006
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Article