Synthesis of the louisianin alkaloid family via a 1,2,4-triazine inverse-electron-demand Diels-Alder approach.
J Org Chem
; 74(21): 8343-54, 2009 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-19780559
ABSTRACT
Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin family, from a conveniently prepared 1,2,4-triazine and via a common tetrasubstituted pyridine intermediate. This study includes the synthesis of louisianin B in both racemic form and as the (-)-enantiomer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Triazinas
/
Compostos Alílicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article