GSK3: a possible link between beta amyloid peptide and tau protein.
Exp Neurol
; 223(2): 322-5, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19782073
ABSTRACT
Tau is a neuronal microtubule-associated phosphoprotein that is highly phosphorylated by glycogen synthase kinase 3 (GSK3). Tau phosphorylation by GSK3 regulates tau binding to microtubules, tau degradation and tau aggregation. Tau phosphorylation is important in Alzheimer disease pathology and in other tauopathies. In Alzheimer disease, it has been proposed that the peptide beta amyloid promotes GSK3 activation, resulting in tau phosphorylation. In this work, we review the links between beta amyloid peptide, tau protein and GSK3 that occur in familial Alzheimer disease. We also discuss the possible links between GSK3 and sporadic Alzheimer disease. Finally, we include a brief review of the pathology of animal models overexpressing GSK3.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Peptídeos beta-Amiloides
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Proteínas tau
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Quinase 3 da Glicogênio Sintase
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article