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Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.
Williams, David S; Cash, Alan; Hamadani, Lara; Diemer, Tanja.
Afiliação
  • Williams DS; Departments of Pharmacology and Neurosciences, UCSD School of Medicine, University of California-San Diego, La Jolla, CA 92130, USA. dswilliams@ucla.edu
Aging Cell ; 8(6): 765-8, 2009 Dec.
Article em En | MEDLINE | ID: mdl-19793063
ABSTRACT
Reduced dietary intake increases lifespan in a wide variety of organisms. It also retards disease progression. We tested whether dietary supplementation of citric acid cycle metabolites could mimic this lifespan effect. We report that oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO/DAF-16, and the energy sensor, AMP-activated protein kinase, indicating involvement of a pathway that is also required for lifespan extension through dietary restriction. These results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health-related benefits of dietary restriction.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxaloacetatos / Transdução de Sinais / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Fatores de Transcrição Forkhead / Proteínas Quinases Ativadas por AMP / Longevidade Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxaloacetatos / Transdução de Sinais / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Fatores de Transcrição Forkhead / Proteínas Quinases Ativadas por AMP / Longevidade Idioma: En Ano de publicação: 2009 Tipo de documento: Article