Oxidative stress and immune-suppression in Toxoplasma gondii positive blood donors: implications for safe blood transfusion.
J Egypt Soc Parasitol
; 39(2): 421-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19795749
ABSTRACT
The sero-markers of Toxoplasma gondii and oxidative stress (OS) were determined in a group of 260 blood donors attending blood banks in Greater Cairo. Twenty-four blood donors with the highest anti-T. gondii IgG titre were tested for IgG avidity. Of whom 4 (16.6%) had low IgG avidity antibodies, documenting recent infection, 6 (25%) had borderline avidity and 14 (58.3%) showed high avidity, ruling out recent infection. The plasma level of malondialdehyde (MDA) was significantly higher and activity of glutathione peroxidase (GSH-Px) and level of tocopherol (alpha, gamma, & lambda) fractions (P < 0.001) were lower in T. gondii-seropositive than in seronegative blood donors. This significant alteration in redox status between seropositive and seronegative donors suggested a degradation of their antioxidant enzymes caused by OS induced by increased free radicals attributable to toxoplasmosis infection. T. gondii infection also had a prominent influence on the association between OS biomarkers and immune-suppression status in seropositive donors.
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Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Doadores de Sangue
/
Anticorpos Antiprotozoários
/
Toxoplasmose
/
Estresse Oxidativo
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article