Association of intraocular pressure with the metabolic syndrome and novel cardiometabolic risk factors.
Eye (Lond)
; 24(6): 1037-43, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19816514
ABSTRACT
BACKGROUND AND AIMS:
This study aimed to investigate the association of intraocular pressure (IOP) with the metabolic syndrome and other emerging cardiometabolic risk factors.METHODS:
A total of 1112 participants undergoing a health check-up in a community hospital were recruited. All participants underwent ophthalmological examination including IOP measurement.RESULTS:
Participants with metabolic syndrome had significantly higher IOP than those without metabolic syndrome (mean IOP+/-SD 15.07+/-2.74 vs 14.29+/-2.72 mm Hg, P=2x10(-4)). Each additional component of the metabolic syndrome was associated with a mean increase in IOP of 0.33 mm Hg (95% confidence interval 0.18-0.48, trend P<0.0001). Other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, were also associated with IOP (P<0.0001, 0.002, and 0.01, respectively). However, we did not find significant association of plasma apolipoprotein A, apolipoprotein B1, homocysteine, or highly sensitive C-reactive protein levels with IOP. IOP was also not associated with measures of subclinical atherosclerosis including brachial-ankle pulse wave velocity, ankle-brachial index, and vertebral artery flow.CONCLUSION:
Metabolic syndrome and other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, are strongly associated with IOP.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Síndrome Metabólica
/
Pressão Intraocular
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article