Antibacterial activity of synthetic fire ant venom: the solenopsins and isosolenopsins.
Am J Med Sci
; 338(4): 287-91, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19826319
ABSTRACT
BACKGROUND:
We determined the in vitro activity of 9 synthetic fire ant venom alkaloids (+/-)-solenopsin A, (2R, 6R)-solenopsin A, (2S, 6S)-solenopsin B, (+/-)-isosolenopsin A, (2S, 6R)-isosolenopsin A,(2R, 6S)-isosolenopsin A, (+/-)-isosolenopsin B, (2S, 6R)-isosolenopsin B, and (2R, 6S)-isosolenopsin B against 6 species of bacteria (Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Stenotrophomonas maltophilia, and Pseudomonas aeruginosa).METHODS:
The minimum inhibitory concentration and minimum bacteriocidal concentration were determined in accordance with the Clinical Laboratory Standards Institute guidelines. Time kill studies used American Type Culture Collection bacterial isolates tested at 5 times the minimum inhibitory concentration.RESULTS:
None of the venom alkaloids inhibited E. coli or P. aeruginosa, whereas all the alkaloids inhibited S. pneumoniae. Only 4 alkaloids inhibited S. pneumoniae, S. aureus, and S. maltophilia. Time-kill kinetics indicates that all 4 active alkaloids had bactericidal activity.CONCLUSIONS:
Specific isomers of synthetic fire ant venom alkaloids have antibacterial activity against human pathogens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides
/
Venenos de Formiga
/
Antibacterianos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article