Growth factors, inflammatory cytokines and postnatal bone strength in preterm infants.
J Pediatr Endocrinol Metab
; 22(8): 733-40, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19845124
ABSTRACT
AIM:
To assess the relationships between growth factors, inflammatory cytokines and postnatal bone development in preterm infants.METHODS:
Fifty premature infants (24-32 weeks gestational age, mean birth weight 1,024 +/- 50 g) participated in the study. Bone strength was determined weekly by quantitative ultrasound measurements of bone speed of sound (SOS). Blood serum measurements of growth factors included circulating IGF-I and GH binding protein. Measurements of circulating cytokines included the pro-inflammatory mediator interleukin (IL)-6, and the anti-inflammatory mediator IL-1 receptor antagonist. Samples were collected when the preterm infants were stabilized and prior to discharge.RESULTS:
Despite a significant increase in body weight (from 1,024 +/- 50 to 2,420 +/- 59 g, p < 0.001) and body length (from 35.4 +/- 0.6 to 44.6 +/- 0.4 cm, p < 0.001) there was a significant decrease in bone SOS during the follow-up period. There was a significant increase in growth factors and a decrease in inflammatory cytokines during the follow-up. Participants were divided into preterm infants who increased bone SOS (bone gainers, n = 16, from 2,867 +/- 38 to 2,910 +/- 41 m/sec), or decreased bone SOS (bone losers, n = 34, from 2,967 +/- 33 to 2,818 +/- 28 m/sec) during follow-up. Baseline bone SOS was significantly lower in the bone gainers. Baseline circulating growth factors were higher and inflammatory cytokines lower in the bone gainers; however, only the difference in IL-6 reached statistical significance (6.4 +/- 1.6 versus 10.5 +/- 1.2 pg/ml, in bone gainers and losers, respectively; p < 0.05).CONCLUSIONS:
Preterm infants with lower bone SOS at birth tend to 'catch-up' during early postnatal weeks. Increases in bone strength in preterm infants were associated with reduced inflammatory state as suggested by lower levels of circulating IL-6.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Fator de Crescimento Insulin-Like I
/
Proteínas de Transporte
/
Interleucina-6
/
Proteína Antagonista do Receptor de Interleucina 1
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article