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Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Ioannidis, Stephanos; Lamb, Michelle L; Davies, Audrey M; Almeida, Lynsie; Su, Mei; Bebernitz, Geraldine; Ye, Minwei; Bell, Kirsten; Alimzhanov, Marat; Zinda, Michael.
Afiliação
  • Ioannidis S; Department of Cancer Chemistry, AstraZeneca R&D Boston, Waltham, MA 02451, USA. Stephanos.Ioannidis@astrazeneca.com
Bioorg Med Chem Lett ; 19(23): 6524-8, 2009 Dec 01.
Article em En | MEDLINE | ID: mdl-19857966
The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Pirazóis / Inibidores de Proteínas Quinases / Janus Quinase 2 / Descoberta de Drogas Idioma: En Ano de publicação: 2009 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Pirazóis / Inibidores de Proteínas Quinases / Janus Quinase 2 / Descoberta de Drogas Idioma: En Ano de publicação: 2009 Tipo de documento: Article