Systemic idiopathic fibrosis with T-cell receptor gene rearrangement.
Arch Pathol Lab Med
; 115(1): 80-3, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-1987920
ABSTRACT
A case of systemic idiopathic fibrosis was analyzed by Southern blotting with probes to the immunoglobulin heavy chain and T-cell receptor genes. A 45-year-old man presented with bilateral neck swelling. He later developed lower back pain, and findings on a computed tomographic scan were consistent with idiopathic retroperitoneal fibrosis. A biopsy specimen of a neck lesion showed morphologic characteristics typical of idiopathic fibrosing cervicitis. Immunophenotyping of the lesion revealed a polymorphic lymphoid population. Molecular analysis with the use of probes to the immunoglobulin and T-cell receptor genes disclosed a germline DNA pattern for the immunoglobulin gene and a rearranged pattern for the T-cell receptor gene.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fibrose Retroperitoneal
/
Rearranjo Gênico do Linfócito T
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article