FlyTF: improved annotation and enhanced functionality of the Drosophila transcription factor database.
Nucleic Acids Res
; 38(Database issue): D443-7, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19884132
ABSTRACT
FlyTF (http//www.flytf.org) is a database of computationally predicted and/or experimentally verified site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. The manual classification of TFs in the initial version of FlyTF that concentrated primarily on the DNA-binding characteristics of the proteins has now been extended to a more fine-grained annotation of both DNA binding and regulatory properties in the new release. Furthermore, experimental evidence from the literature was classified into a defined vocabulary, and in collaboration with FlyBase, translated into Gene Ontology (GO) annotation. While our GO annotations will also be available through FlyBase as they will be incorporated into the genes' official GO annotation in the future, the entire evidence used for classification including computational predictions and quotes from the literature can be accessed through FlyTF. The FlyTF website now builds upon the InterMine framework, which provides experimental and computational biologists with powerful search and filter functionality, list management tools and access to genomic information associated with the TFs.
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Base de dados:
MEDLINE
Assunto principal:
Biologia Computacional
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Proteínas de Drosophila
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Bases de Dados Genéticas
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Bases de Dados de Ácidos Nucleicos
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Drosophila melanogaster
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article