[Mechanisms of functioning and regulation of mammalian sinoatrial node].
Usp Fiziol Nauk
; 40(4): 21-41, 2009.
Article
em Ru
| MEDLINE
| ID: mdl-19886187
ABSTRACT
Actual data concerning mechanisms of automaticity in sinoatrial node, which acts as a primary pacemaker in mammalian heart, is reviewed. Studies dealing with ionic currents, maintaining automatic generation of excitation in the sinoatrial cells, and possible role of intracellular calcium turnover are discussed. Special attention is given to the differences between the central and peripheral parts of sinoatrial node, phenomenon of intranodal pacemaker shift resulting from that differences and possible role of pacemaker shift in the modulation of the sinus rhythm. Mechanisms of sinus rhythm regulation under the action of acetylcholine and noradrenalin are also discussed in detail.
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Base de dados:
MEDLINE
Assunto principal:
Nó Sinoatrial
/
Fenômenos Fisiológicos Cardiovasculares
/
Modelos Cardiovasculares
Idioma:
Ru
Ano de publicação:
2009
Tipo de documento:
Article